Moyamoya Disease, Remote Ischemic Preconditioning
Conditions
Brief summary
In the present study, we evaluated whether RIPC with RIPostC reduce the major neurocomplication in patients undergoing STA-MCA anastomosis.
Interventions
PROCEDURERIPC with RIPostC
The sphygmomanometer is closed to the lower limb and the cuff is inflated and the pressure is increased by 30 mmHg higher than the systolic blood pressure of each patient for 5 minutes. The loss of the distal pulse is confirmed by Doppler in the dorsalis pedis pulse. If there is a pulse, increase the pressure until it disappears. After 5 minutes of ischemia time, the cuff is deflated to confirm that the pulse has returned and has a reperfusion time of 5 minutes. A total of 4 cycles of 5 cycles of ischemic time and 5 minutes of reperfusion time are performed. (Estimated total 40 minutes) When the skull is started to close, RIpc with RIPostC group performs RpostC and the method is the same as the above RIPC method. (Estimated total 40 minutes)
Sponsors
Seoul National University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
1. American Society of Anesthesiologists 2. Adults 18 to 65 years of age 3. In patients with planned MCA-STA anastomosis under general anesthesia 4. Patients who pre-agreed to the study
Exclusion criteria
1. If there is a history of peripheral vascular arterial or venous disease 2. If there is a previous history of peripheral nerve disease 3. Other brain or cerebrovascular disease 4. In case of serious cardiovascular disease, pulmonary disease, kidney disease 5. Patients who do not agree with the test
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of major adverse event | postoperative one month | hyperperfusion syndrome, hypoperfusion, EDH, SAH, acute infarction |
Countries
South Korea
Outcome results
None listed