Crohn Disease, Spondyloarthritis
Conditions
Brief summary
The FLORACROHN project aims to compare gut microbiota of patients suffering from Crohn's disease (CD) associated or not to spondylarthritis (SpA). 3 groups of patients will be analyzed: patients suffering from CD alone, patients suffering from SpA alone, patients suffering from CD and SpA. Fecal microbiota will be determined by 16SRNA gene sequencing.
Interventions
OTHERanalysing microbiota
16SRNA gene sequencing of feces
Sponsors
Central Hospital, Nancy, France
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients with Crohn's disease and axial spondyloarthritis according to the criteria below. * Patients with Crohn's disease (CT patients) diagnosed according to clinical, biological, radiological, endoscopic and / or histological criteria for 3 months. With diagnosis of spondyloarthritis exclusion on modified ASAS and / or New York criteria. * Patients with axial spondyloarthritis (SpA patients) diagnosed according to the modified ASAS and / or New York criteria with exclusion diagnosis of Crohn's disease. * Patient with the capacity to give free and informed consent.
Exclusion criteria
Antecedent of colonic resection * Antibiotic or colonic colonoscopy preparation in the 8 weeks prior to stool collection (against temporary indication = collection possible before colic preparation or on the first saddle after the start of the colic preparation). * Ostomy at time of collection * BMI\> 30 * extreme diet * unbalanced diabetes * Patient under guardianship, under curatorship or under safeguard of justice
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Microbiota analysis | 6 months after last patient inclusion | 16SRNA gene sequencing |
Countries
France
Outcome results
None listed