Bypass Complication, Respiratory Complication
Conditions
Brief summary
Does the duration of cardiopulmonary bypass, and aortic cross clamping affects the post operative pulmonary function.
Detailed description
Cardiac surgery usually is done under cardiopulmonary bypass. As the blood contacts with the artificial tubing of the circuit, there is release of mediators which affects pulmonary function. Of no doubt that the duration of cardiopulmonary bypass, and cross clamping time, will affect the spell over of such mediators. Follow up of the pulmonary function, and arterial blood gas is mandatory in such group of patients.
Interventions
PROCEDUREaortic cross clamping
duration of cross clamping, less than 90 minutes, or more than 90 minutes
Sponsors
Assiut University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* adult patients * elective open heart surgery
Exclusion criteria
* Patients with myocardial ischemia or previous infarction * low ejection fraction \<30% * history of AF * implanted pacemaker * uncontrolled hypertension * renal impairment (creatinine \>1.8 mg/dl) * hepatic dysfunction * insulin dependent diabetes * chronic pulmonary disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| quality of oxygenation | 48 hours postoperative | PaO2 mmHg |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| time to extubation | 24 hours postoperative | time to extubate in minutes |
| ventilation | 48 hours postoperative | respiratory rate (breath/minute) |
| carbon dioxide | 48 hours | PaCO2 mmhg |
Countries
Egypt
Outcome results
None listed