Kidney Function, Kidney Transplant; Complications, Delayed Graft Function
Conditions
Keywords
furosemide stress test, kidney transplantation, urine output, perioperation, delayed graft function
Brief summary
Furosemide is an old drug that has been used frequently in the postoperative period of kidney transplantation, aiming to achieve adequate urine output. There is no previous study that directly evaluate the urine response to standardized dose of furosemide in the postoperative period. The objective is to measure the urine output after standardized dose of furosemide is delivered, as a biomarker to predict the graft function in perioperative period.
Interventions
Furosemide 1.5 mg/kg intravenously at 3 hours post-reperfusion of kidney allograft
Sponsors
King Chulalongkorn Memorial Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Deceased donor kidney transplantation at KCMH * informed consent is accepted
Exclusion criteria
* Known allergy to furosemide * Surgical complication of allograft * Urgently needed for dialysis (refractory hypervolemia, uremic symptoms, and hyperkalemia)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Urine output | 6 hours | Urine output per hour (milliliters/hour) after furosemide injection |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Delayed graft function | 7 days | Delayed graft function is defined by the necessity of dialysis within the first week after kidney transplantation. (yes/no) |
| Creatinine reduction ratio | At postoperative day 0,7 and 14 | Ratio of serum creatinine at postoperative day 7 and 14 to day-zero creatinine |
Countries
Thailand
Contacts
Primary ContactSuwasin udomkarnjananun, M.D.
Outcome results
None listed