The Interactive Physical and Cognitive Exercise System

The Interactive Physical and Cognitive Exercise System (iPACES™): A Neuro-exergame for Preventing Alzheimer's and Ameliorating Cognitive Impairment

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03069391

Acronym

iPACES™

Enrollment

Registered

2017-03-03

Start date

2017-03-04

Completion date

2022-06-30

Last updated

2020-03-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aging, Alzheimer Disease, Early Onset, Cognitive Change, Cognitive Impairment, MCI, Mild Cognitive Impairment, Neurocognitive Disorder

Keywords

exercise, exergame

Brief summary

This study is intended to clarify the benefits to brain health and thinking processes that result from different forms of exercise. In particular, this study will investigate the possible benefits of physical exercise (such as pedaling an under-table stationary elliptical) or mental exercise (such as playing a videogame on a portable tablet), or combining these activities together (as in the iPACES™ exergame).

Interventions

BEHAVIORALphysical exercise alone (PES) first

following 2-week placebo for all participants, participants in this arm will then start their active intervention with a randomly assigned 2-week physical exercise-only intervention, then 2-week cognitive exercise-only intervention, then 2-week and 3 month intervals of iPACES™ (interactive physical and cognitive exercise)

DEVICEcognitive exercise alone (iCE) first

following 2-week placebo for all participants, participants in this arm will then start their active intervention with a randomly assigned 2-week cognitive exercise-only intervention, then 2-week physical exercise-only intervention, then 2-week and 3 month intervals of iPACES™ (interactive physical and cognitive exercise)

DEVICEinteractive Physical and Cognitive Exercise (iPACES™)

Study design

Allocation

NON_RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

NONE

Intervention model description

Crossover RCT: participants are randomly assigned to start with one form of intervention and then crossover to another form of the intervention.

Eligibility

Sex/Gender

ALL

Age

50 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* co-residing older adults (e.g., spouses, partners, roommates, relatives) * both at least 50 years of age * normative/typical cognitive function or those with Mild Cognitive Impairment (MCI) or mild Neurocognitive Disorder (mNCD) or early Alzheimer's disease * adequate vision and dexterity for on-screen assessments * able to pedal an under-table elliptical * permission of primary care provider and cardiologist (if applicable)

Exclusion criteria

* history of seizure * Parkinson's disease * significant dementia/memory loss

Design outcomes

Primary

Measure	Time frame	Description
executive function composite score	change over time from baseline to 3 months	comprised of scores from Stroop, Trails, and Flanker

Secondary

Measure	Time frame	Description
brain-derived neurotrophic factor (BDNF)	change over time from baseline to 3 months	change in amount in saliva sample over time (pg/ml) per ELISA
Sit-Stand Test	change over time in score from baseline to 3 months	scored performance on time and technique to move from sitting on floor to standing

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026