Cervical Cancer
Conditions
Keywords
cervical cancer, NSRH, RH, urine flow mechanics, anorectal dynamics
Brief summary
Cervical cancer in young patients increased significantly in recent years, and early surgical treatment for patients with 5 years of survival rate is as high as 90%, But the traditional extensive hysterectomy (RH) caused by intraoperative pelvic autonomic nerve may damage the bladder and rectum and the incidence of complications such as sexual dysfunction is nearly 25% to 80%, thus seriously affect the patient's quality of life.Pelvic autonomic nerve preservation system of extensive hysterectomy (NSRH) can decrease the complications of above, but at home and abroad mainly adopts pulling the urine tube time, determination methods of residual urine volume, bladder function are studied in only a few scholars urine flow mechanics method is applied to carry on objective appraisal limited cases of postoperative bladder function, and the anorectal function damage ，we can use the anorectal dynamics to get objective index of anorectal function .overall research lack of large sample research of dynamic system. No objective index to evaluate the anorectal function In the early stage of the study, we have conducted about uterine ligament, sacral ligaments and nerve distribution of the bladder cervix vaginal ligament of experimental research, provide the neural anatomy basis for NSRH operation, and based on research for innovative operation scheme is put forward.Proposed on the basis of the above research, this study adopt the internationally used - urine flow mechanics, the method for evaluating the bladder function of NSRH, RH, two kinds of the injured function of bladder surgery patients before and after operation of comparative study, the change of dynamic assessment before and after surgery in patients with bladder function,and the anorectal function dameage and than provide the basis for further treatment.
Interventions
PROCEDUREnerve sparing radical hysterectomy
Type C1 radical hysterectomy,that is nerve sparing radical hysterectomy, requires separation of two parts of the dorsal parametria: the medialpart , which entails recto -uterineandrecto-vaginal ligaments, and the lateral laminar structure, also called mesoureter, which contains the hypogastric plexus. Furthermore, type C1 requires only a partial dissection of the ureter from the ventral parametria, which is usually asymmetric towards more extensive resection of the medial leaf of the cranial (above the ureter) part of the ventral parametria .
PROCEDUREradical hysterectomy
In the C2 type, the ureter is completely dissected from the ventral parametria up to the urinary bladder wall. Defining the resection limits on the longitudinal (deep parametrial or vertical) plane is crucial for distinguishing between types C1 and C2.
Sponsors
Chen Chunlin
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Cervical Cancer FIGO(2009) IA2,IB1,IB2,IIA1,IIA2
Exclusion criteria
* Cervical Cancer FIGO(2009) \> IIb * Patients received radiotherapy before opration * The patient refused to sign a consent form.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Survival rates | 5 years after operation | Live or die |
| The recurrence rate | 5 years after operation | Whether the tumor recurrence |
| Abdominal pressure urination | 1 years after operation | Urine flow dynamic test results |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Abdominal pressure urination | 3 months after operation | Urine flow dynamic test results |
| the results of anorectal dynamics | 1 months after opration | the results of anorectal dynamics |
Countries
China
Outcome results
None listed