Pancreatic Islet Quality Control
Conditions
Keywords
Islet Transplantation
Brief summary
Islet quality control after pancreatic islets isolation process is insufficient. The Islet Chip study proposes to develop a bio-sensor that will allow a multi-parametric analysis of islet graft based on measurement of islet membrane electric potential.
Detailed description
Islet quality control after pancreatic islets isolation process is insufficient. The Islet Chip study proposes to develop a bio-sensor that will allow a multi-parametric analysis of islet graft based on measurement of islet membrane electric potential. The project aims to : * develop the bio-sensor necessary to measure islet membrane electric potential * develop interface between bio-sensor and user * correlate analysis data collected by bio-sensor with metabolic results of islet graft
Interventions
None listed
Sponsors
University Hospital, Bordeaux
University Hospital, Grenoble
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Inclusion criteria
* Patients enrolled in STABILOT Pancreatic Islet cell graft protocol and willing to participate to ISLET CHIP
Exclusion criteria
* Patients not enrolled in STABILOT Pancreatic Islet cell graft or patients that signed the form expressing their refuse to participate to ISLET CHIP.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Beta-score | 6 months in average before second islet graft | Beta-score in continuous variable, using the last Beta-score known before the second islet graft. Beta-score is a composite score that reflects pancreatic islet graft function after transplantation and measured from the following criteria: severe hypoglycemia, HbA1c, stimulated C-peptide, fasting glucose, insulin dose or oral diabetes, glycemic variability. |
Countries
France, Switzerland
Contacts
Primary ContactSandrine LABLANCHE, MD, PhD
Backup ContactMyriam HADDOUCHE
Outcome results
None listed