Pediatric Multiple Sclerosis
Conditions
Brief summary
Most youth with MS experience symptoms such as depression and fatigue. In addition, cognitive issues, especially with attention and memory occur frequently. However, little is known about interventions that might work to improve these symptoms. In other work, the investigators have shown that higher levels of physical activity are associated with lower levels of depression and fatigue. Importantly, sleep problems are frequently encountered in youth with MS, and were seen in 60% of surveyed youth with MS in the investigators preliminary work. Modifiable lifestyle factors such as sleep and physical activity (PA) may play a key role in ameliorating common symptoms in pediatric MS. However, sleep has not been objectively described in pediatric MS, and the relationship between PA and sleep is poorly understood. This study aims to address these gaps.
Interventions
DEVICEActigraphy
Actiwatch Spectrum Plus will be worn on the non-dominant wrist 24 hours/day for seven days. Actigraphy is a valid and reliable objective measure of sleep patterns, including sleep quality, duration, and timing when compared to polysomnography (PSG).
Sponsors
University of Alabama at Birmingham
Queen's University
The Hospital for Sick Children
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
10 Years to 18 Years
Healthy volunteers
Yes
Inclusion criteria
1. Children ages 10 to 17 years, 11 months; 2. MS diagnosis following standard definitions (IPMSSG); 3. Healthy controls will include any child without a history of disease or disability
Exclusion criteria
1. Inability to communicate or understand English; 2. Those within 30 days of a relapse; 3. Children who exhibit severe respiratory problems at baseline (e.g. use of tracheotomy)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Sleep quality, duration and timing | 7 days | This will be determined by actigraphy, using the ActiwatchSpectrum Plus, worn on the non-dominant wrist 24 hours/day for seven days. Participants will also complete a sleep diary, the Children's Behavior Check List Sleep Composite, Children's Sleep Habits Questionnaire (CSHQ) and the Pediatric Sleep Questionnaire to derive contextual information about sleep and to identify sleep problems. |
Countries
Canada
Outcome results
None listed