Chronic Pain, Cluster Headache, Neuropathic Pain, Post-Zoster Neuralgia, Post Zoster Pain, Trigeminal Neuralgia
Conditions
Keywords
regional-anaesthesiological infiltration, block series, invasive pain treatment
Brief summary
There is a significant debate whether local infiltration techniques may be a method to treat complicated chronic pain syndromes, e.g. refractory headache. Until now there is a lack of evidence regarding efficacy of this treatment especially in long term follow up. Similarly, indication and management are under debate. Aim of this trial is to analyse pain scores during first treatment with anaesthesiological infiltration series.
Interventions
PROCEDUREregional-anaesthesiological infiltration
Patients with therapy refractory chronic pain are treated with local infiltration techniques using e.g. local anaesthetics, opioids or drug combinations. Targeted structures are e.g. Ganglion stellatum, Ganglion pterygopallatinum, Trigeminal nerve branches (V1-V3). Patients receive a context- sensitive number of blocks in a series of infiltrations depenting on their pain course.
Sponsors
Charite University, Berlin, Germany
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* patients with chronic pain disease undergoing regional-anaesthesiological infiltration series
Exclusion criteria
* pregnancy * patients in legal custody * age \<18 years
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| NRS reduction during therapy | 2 weeks | Reduction (relative and absolute) of pain during series of infiltrations comparing NRS scores before and after infiltrations |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Number of blocks in a series | 4 weeks | Number of blocks in a series to achieve the targeted NRS reduction |
| Time till recurrent pain | 24 weeks | Time until a new series of blocks is requested by the patient |
| clinical course of pain | 2 weeks | NRS development during series of infiltrations |
| type of infiltration | 2 weeks | location of infiltrations with medication used |
| co-parameters of pain chronification | 2 weeks | co-factors of pain like co-morbidity, duration of pain disease, psychological diseases and association with primary outcome |
Countries
Germany
Outcome results
None listed