Healthy
Conditions
Keywords
myocardial fibrosis, cardiac function, ageing
Brief summary
In normal ageing, the impact of myocardial fibrosis on myocardial function is unclear as diastolic function is reported to change according to age. The objective is to explore the relationship between myocardial function changes, with local (T1 and diffusion) fibrosis measures with Magnetic Resonance Imaging (MRI) as well as global measures of fibrosis (skin auto-fluorescence and collagen blood-biomarkers).
Interventions
BIOLOGICALBlood sampling
Blood sampling will be performed at inclusion to investigate some biological eligibility criteria, and the day of MRI in order to analyse fibrosis biomarkers and collagen synthesis biomarkers
DEVICEMRI
MRI will be performed to measure interstitial fibrosis
BIOLOGICALSkin auto-fluorescence
Skin auto-fluorescence measures will be performed to measure advanced glycation end-products (AGE) produced by collagen degradation
Sponsors
Hospices Civils de Lyon
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* physical activity ≤ 3 x(30') per week * no history of smoking, diabetes, myocardial infarction, heart failure, hypertension (\<140 or \<90 mmHg) and no anti-hypertensive or cardiovascular-related medications * no familial history of early myocardial ischemia * body mass index (BMI) \<30kg/m2 * normal routine lipid blood analysis * glycemia \<1.26g/l * normal electrocardiogram (ECG)
Exclusion criteria
* arrhythmia * hepatic insufficiency * pregnancy * claustrophobia * MRI contrast allergy, * general contraindications to MRI such as pacemaker, etc.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Regional myocardial strain | The day of MRI | Segmental measures of systolic and diastolic strains with magnetic resonance imaging (MRI) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| MRI T1 value | The day of MRI, before gadolinium injection | This value is an indicator of interstitial fibrosis and extracellular volume |
| Apparent Diffusion Coefficient (ADC) with MRI | The day of MRI | ADC is measured with diffusion weighted imaging |
| Blood carboxy-terminal propeptide of procollagen type I (PICP) rate | The day of MRI | Collagen blood biomarker analysis |
| Blood amino-terminal propeptide of procollagen type III (PIIINP) rate | The day of MRI | Collagen blood biomarker analysis |
| Advanced Glycation End-products (AGE) rate | The day of MRI | Skin auto-fluorescence AGE measures |
Countries
France
Contacts
PRINCIPAL_INVESTIGATORPierre CROISILLE, MD, PhD
CHU SAINT-ETIENNE
Outcome results
None listed