Preterm Infant Multicentre Growth Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03064022

Acronym

PreMGS

Enrollment

1275

Registered

2017-02-24

Start date

2009-02-28

Completion date

2019-06-30

Last updated

2020-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Preterm Infant

Keywords

weight gain, head circumference, length, neurodevelopment, overweight

Brief summary

The purpose of this study is to improve health professionals understanding of preterm infant growth patterns, and to determine if early growth patterns predict risks of adverse metabolic and cognitive outcomes.

Detailed description

The purpose of this study is: To improve health professionals understanding of preterm infant growth patterns, and to determine if growth patterns (rapid early growth in the first 2 weeks of life, weight less than the 10th percentile at the time of discharge) predict risks of adverse metabolic outcomes (measured as overweight at age 3) once the following variables are controlled for: size at birth (z-score), neonatal morbidities, social determinants of health, and nutritional adequacy in the neonatal intensive care unit (NICU). To assess diagnostic accuracy of 36-week anthropometric weight, length and head circumference \<10th and \<3rd percentiles to predict preterm infant cognitive impairment.

Interventions

OTHERGrowth

Some preterm infants grow at higher rates than others

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

No minimum to 3 Years

Healthy volunteers

Inclusion criteria

* \< 32 weeks gestational age at birth

Exclusion criteria

* infants who had congenital anomalies or those who died prior to discharge

Design outcomes

Primary

Measure	Time frame	Description
Neurodevelopment	Twenty-one months of age	Neurodevelopment (Bayley scale scores II and III), diagnoses of cerebral palsy, or other neurologic impairments) measured

Secondary

Measure	Time frame	Description
Overweight	Three years of age	Overweight will be defined as body mass index
Growth patterns	From birth to 50 weeks post-menstrual age	Growth patterns of preterm infants relative to the Fenton growth chart

Countries

Canada

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 21, 2026