Liver Diseases
Conditions
Brief summary
Gastrointestinal endoscopy is a frequent procedure in the patients with advanced liver disease. It requires variable degree of sedation ranging from minimal sedation to general anesthesia aiming for relieving pain, anxiety, and bad memories of the procedure. In conscious sedation, patients are able to make purposeful responses to auditory and tactile clues, with maintenance of ventilatory and circulatory stability. while, in deep sedation, patients respond only to painful stimuli, and airway support is frequently required. At the level of general anesthesia, patients are unresponsive, and airway support is mandatory.
Detailed description
The aim of this study is to compare use of propofol or midazolam as sedative for patients with advanced liver disease presented for gastrointestinal endoscopy.
Interventions
DRUGFentanyl
fentanyl 0.5 ug/kg
DRUGPropofol
Propofol 1 mg/kg i.v
DRUGMidazolam
Midazolam 3 mg i.v
Sponsors
Tanta University
Sherief Abd-Elsalam
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
40 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Patients aged between 40 and 60 years old. * With Child score B or C * Presented for elective gastrointestinal endoscopy
Exclusion criteria
* Emergent condition like hematemesis. * Patients with moderate to severe hepatic encephalopathy. * Patients with hepatopulmonary syndrome. * Patients with known or suspected hypersensitivity to the used medication were also excluded from the study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Level of sedation | 6 months | Level of sedation using Ramsay sedation agitation score at before induction of sedation |
Countries
Egypt
Contacts
Primary ContactSherief Abd-Elsalam, MD
Outcome results
None listed