Pediatric Cataract, Congenital Cataract, Traumatic Cataract, Visual Outcome, Genetic Anticipation
Conditions
Brief summary
The purpose of this study is to evaluate the long-term visual outcome of the cataract surgery using a large-scale and comprehensive database of pediatric cataract participants, including congenital and traumatic cataract. The investigators will further investigate into the various genetic and environmental factors that may contribute to the pathogenesis of pediatric cataract.
Interventions
PROCEDUREintraocular lens implantation
1）Pediatric cataract patients with intraocular lens implantation and those without intraocular lens implantation；2）Traumatic cataract patients with intraocular lens implantation and those without intraocular lens implantation
Sponsors
Eye & ENT Hospital of Fudan University
Evidence Based Cataract Study Group
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
2 Months to 20 Years
Healthy volunteers
No
Inclusion criteria
* Clinical diagnosis of pediatric cataract * Must be able to cooperate with the ophthalmic examination
Exclusion criteria
* Clinical diagnosis of mental illness * Mentally disabled
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Differences in the visual outcomes of pediatric cataract patients. | Follow-up until ten years after surgery. | Visual outcomes are evaluated including visual acuity with or without correction, refractive changes, intraocular pressure, fundus function, fixation type, vision development, growth of axial length, contrast sensitivity and other visual outcome measurements. |
| Genetic diversity based on biospecimen samples of pediatric cataract patients. | Analyzed within six months after surgery. | Sequencing of genes (including exons, promoters, 5' UTR and 3' UTR sequences) on a large scale to intensively investigate into the sites and functions of single nucleotide polymorphism (SNP) correlated with clinical features of congenital cataract patients, compared to traumatic cataract patients.Samples of blood, aqueous humor, anterior capsular membranes and lens tissues were applied for the genetic analysis. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Differences in the clinical phenotypes of pediatric cataract patients. | Evaluated before receiving the cataract surgery. | Cataract type and severity of ametropic cataract patients are evaluated and images are captured before receiving the cataract surgery. |
Countries
China
Contacts
Primary ContactYi Lu, M.D.
Outcome results
None listed