Breast Cancer Female
Conditions
Brief summary
The Pecs block (pectoral nerves block) is an easy and reliable superficial block inspired by the infraclavicular block approach and the intercostal abdominis plane blocks . Many additives were used in combination with local anesthetics in Pecs block to prolong the postoperative analgesia (fentanyl, dexmedetomidine).
Detailed description
60 patients scheduled for modified radical mastectomy surgery under general anesthesia. Group I (Bupivacaine group): patients underwent modified radical mastectomy were given preoperative ultrasound guided modified Pecs block with 30 mL of 0.25% bupivacaine divided into 10 ml injected between the pectoralis muscles on the interfascial plane, and 20 ml injected between the Pectoralis minor muscle and the serratus muscle.Group II (Bupivacaine + Dexmedetomidine group) : preoperative ultrasound guided modified Pecs block with 30 mL of 0.25% bupivacaine plus Dexmedetomidine (1 µg/kg) divided into 20 ml injected between the pectoralis muscles on the interfascial plane , and 10 ml injected between the Pectoralis minor muscle and the serratus muscle.
Interventions
DRUGDexmedetomidine Injection [Precedex]
ultrasound guided modified Pecs block with 30 mL of 0.25% bupivacaine (markyrene R sigma -Tec, Egypt) plus (1 µg/kg) Dexmedetomidine Injection \[Precedex\]
ultrasound guided modified Pec's block with 30 mL of 0.25% bupivacaine divided into 10 ml injected between the pectoralis muscles and 20 ml between the Pectoralis minor muscle and the serratus muscl
Sponsors
South Egypt Cancer Institute
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* ASA I - II patients * weight 50- 100 kg * age 18-60 years
Exclusion criteria
* History of bleeding diathesis * Relevant drug allergy * Opioid dependence * Sepsis * Those with psychiatric illnesses that would interfere with perception and assessment of pain will be excluded from the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| I.V patient controlled analgesia (PCA) morphine consumption | 48 hours postoperative | the total dose of I.V patient controlled analgesia (PCA) morphine consumption in the first 48 hours postoperative |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| pain relief | 48 hour | by visual analogue scale measurement |
Countries
Egypt
Contacts
STUDY_DIRECTORsahar m abd elbaqy, professor
manager
Outcome results
None listed