Obstructive Sleep Apnea
Conditions
Brief summary
The purpose of the study is to compare the relative contribution of systemic inflammation vs. Obstructive Sleep Apnea (OSA) severity (as measured by Apnea Hypopnea Index) in predicting cardiovascular and metabolic aberrations associated with mild-to-moderate obstructive sleep apnea.
Interventions
None listed
Sponsors
Milton S. Hershey Medical Center
Study design
Observational model
CASE_ONLY
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Mild to moderate OSA (5≤ AHI \<30) * BMI ≤ 45 * Age ≥ 18 * Men \& Women
Exclusion criteria
* AHI ≥ 30 * BMI \>45 * Current use of steroids or anti-inflammatory medication * Diagnosis of insulin dependent diabetes * Diagnosis of autoimmune disorder * Shiftwork * Current use of CPAP
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Presence of the metabolic syndrome | baseline | At least 3 of the following 5 risk factors must be met in order to have the metabolic syndrome: 1. Elevated waist measurement (≥102 cm for men or ≥89 cm for women) 2. Elevated triglycerides (≥150 mg/dL or use of medication) 3. Low HDL cholesterol (\<50 mg/dL for women or \<40 mg/dL for men or use of medication) 4. Elevated blood pressure (≥130 mmHg systolic or ≥ 85 mmHg diastolic or use of medication) 5. Elevated fasting blood sugar (≥100 mg/dL or use of medication) Source: https://www.nhlbi.nih.gov/health/health-topics/topics/ms |
| Obstructive Sleep Apnea | baseline | AHI from one night polysomnography |
| Markers of systemic inflammation | baseline | CRP, IL-6, TNFa |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Heart rate variability | baseline | from polysomnography |
| Subjective measure of sleepiness | baseline | Epworth Sleepiness Scale |
Countries
United States
Outcome results
None listed