Cardiopulmonary Bypass
Conditions
Keywords
Osmolality, Sodium, CABG, Cardiovascular Diseases, Cardiopulmonary bypass
Brief summary
During the use of Cardiopulmonary Bypass (CPB) for cardiac surgery there is an instant mixture of the patient's blood and the fluid needed to fill the extracorporeal circuit before use. This will change the composition of the body fluids. This study aims to plot these changes in regard to particle concentration (osmolality).
Detailed description
During the use of CPB for cardiac surgery there is an instant mixture of the patient's blood and the fluid needed to prime the extracorporeal circuit. Many studies have pointed to the benefits of using a hyperosmolar prime to counteract formation of tissue oedema. Rapid changes in osmolality may as a serious consequence lead to osmotic demyelination syndrome. At the Heart Centre of Umeå University Hospital, Sweden, there is a tradition of using a hyperosmolar prime. This study aims to explore changes in osmolality during coronary artery bypass grafting surgery by repeated measurements of osmolality and concentration shifts of sodium, glucose and urea in plasma.
Interventions
OTHERBlood sampling
To explore changes in osmolality during coronary artery bypass grafting surgery with the aid of Cardiopulmonary Bypass by repeated measurements of osmolality and concentration shifts of sodium, glucose and urea in plasma.
Sponsors
Umeå University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
60 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Age 60-80 yr * New York Heart Association Functional Classification(NYHA) I-III * Body Surface Area(BSA) 1.8-2.5 m2
Exclusion criteria
* Diabetes * Estimated Glomerular Filtration Rate(eGFR)\<50ml/min/1,73 m2
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in plasma osmolality | Before surgery; repeated during surgery and on postoperative day 1 and 2. | Repeated measurements of plasma osmolality aim to outline changes in plasma osmolality related to the use of hyperosmolar prime. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in osmolar gap | Before surgery; repeated during surgery and on postoperative day 1 and 2. | Analysing urea, sodium and glucose in plasma using the same sampling intervals as for plasma osmolality enables calculation of the osmolar gap and to set its relation to the use of hyperosmolar prime |
Countries
Sweden
Outcome results
None listed