Ketamine Versus Dexmedetomidine With Local Anesthetic in TAP Block

Comparison of the Analgesic Effect of Ketamine Versus Dexmedetomidine Added to Local Anesthetic in TAP Block for Lower Abdominal Cancer Surgery

Status

Completed

Phases

Phase 2Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03060070

Enrollment

Registered

2017-02-23

Start date

2017-03-10

Completion date

2017-07-01

Last updated

2017-07-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lower Abdominal Cancer, Postoperative Analgesia

Brief summary

Comparing the analgesic effects of ketamine and dexmedetomidine when added to local anesthetic in TAP block for postoperative analgesia after lower abdominal cancer surgery.

Interventions

DRUGKetamine

Ketamine at a dose of 0.5mg/kg will be added to bupivacaine 0.25 (total volume 20ml) in each side using sonar guided TAP block

DRUGdexmedetomidine

dexmedetomidine at a dose of 1ug/kg will be added to bupivacaine 0.25 (total volume 20ml) in each side using sonar guided TAP block

DRUGcontrol group

20ml of 0.25% bupivacaine will be injected in each side of the TAP block

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

* All patients ASA I and II to whom abdominal surgery for cancer will be conducted will be included in the study

Exclusion criteria

* Coagulopathies * ASA III or IV, patient refusal, sensitivity to the used drugs

Design outcomes

Primary

Measure	Time frame	Description
postoperative rescue morphine consumption	24 hours postoperative	postoperative rescue morphine consumption

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026