Gingival Recession
Conditions
Brief summary
The purpose of this study was the evaluation of inflammatory and healing profile after root coverage using of Enamel Matrix Derivative. 16 volunteers were selected and submitted to root coverage surgery with subepithelial connective tissue graft, with and without enamel matrix derivative. The patient screening was based in the following inclusion criteria: bilateral recessions in maxillary anterior homologous teeth with aesthetical complaining ou hypersensitivity, non-smokers, healthy and no use of any medication that compromises periodontal health or healing. The split-mouth randomized model was followed in relation to test and control sites. The following clinical parameters were analyzed at baseline and 6-month post-surgery: recession height, recession width, width of keratinized tissue, probing depth, clinical attachment level, and gingival thickness. In addition to the surgical analysis, evaluations of the following inflammatory markers were performed: IL-1β, IL -1RA, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL12, IL-13, IL-15, IL-17, EOTAXIN, FGF, GCSF, GMCSF, IFN-y, IP-10, MCP-1, MIP 1a, PDGF-bb, MIP 1b, RANTES, TNF-α e VEGF. These evaluations were performed at baseline, 7 and 14 days after surgery.
Interventions
PROCEDUREMicrosurgery technique for root coverage
Microsurgery technique for root coverage adapted for macrosurgery
BIOLOGICALMicrosurgery technique for root coverage associated to EMD
Microsurgery technique for root coverage adapted for macrosurgery associated to Enamel Matrix Derivative
Sponsors
Rio de Janeiro State University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
29 Years to 53 Years
Healthy volunteers
Yes
Inclusion criteria
* Bilateral gingival recessions in homologous teeth
Exclusion criteria
* Smokers; * Systemic diseases; * Drugs affecting periodontal health/healing.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Post-surgical pain | 7 days after surgery | Questionnaire with a Visual Analog Scale from 0 (no pain) to 10 (worst pain) |
| Root Coverage Score | 180 days after surgery | A score including root coverage, marginal gingival tissue contour, mucogingival junction alignment, soft tissue texture and gingival colour according to Cairo et al. (1999) |
| Post-surgical Clinical Analysis | 180 days after surgery | Analysis of recession height, recession width, width of keratinized tissue, probing depth, clinical attachment level, and gingival thickness. |
| Changes in Gingival Fluid Biomarkers | Baseline, 7 and 14 days after surgery | Analysis for IL-1β, IL -1RA, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL12, IL-13, IL-15, IL-17, EOTAXIN, FGF, GCSF, GMCSF, IFN-y, IP-10, MCP-1, MIP 1a, PDGF-bb, MIP 1b, RANTES, TNF-α e VEGF by Luminex |
Outcome results
None listed