rTMS in Aphasic Patients With Neuroimage Assessments

Synchronous rTMS and Computer-integrated Speech Training Applied in Aphasic Patients

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03059225

Enrollment

120

Registered

2017-02-23

Start date

2017-02-18

Completion date

2021-12-23

Last updated

2021-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aphasia, Stroke

Keywords

Stroke, Aphasia, rTMS, Functional MRI, Speech training

Brief summary

The refinement of repetitive transcranial magnetic stimulation (rTMS) has highlighted its merit in terms of learning programs as a treatment for aftereffect augmentation. Nevertheless, the efficacy of synchronous rTMS protocol integrated with computer-integrated speech training is not well understood. It is also not clear regarding the efficacy of compound bi-hemispheric stimulation protocol. The aim of the study is to investigate language response to these new strategies and to determine the longevity of the therapeutic outcome. Advanced MR neuroimaging techniques, such as fMRI and DTI, are powerful tools to evaluate the concomitant nervous changes after rTMS treatment on aphasic patients. The knowledge from fMRI and DTI microstructural evolution provides insight into underlined mechanism operating the language improvement.

Detailed description

The efficacy of synchronous rTMS protocol integrated with computer-integrated speech training is not well understood. It is also not clear regarding the efficacy of inhibitory or excitatory stimulation protocol. The aim of the study is to investigate language response to these new strategies and to determine the longevity of the therapeutic outcome. Advanced MR neuroimaging techniques, such as fMRI and DTI, are powerful tools to evaluate the concomitant nervous changes after rTMS treatment on aphasic patients. The knowledge from fMRI and DTI microstructural evolution provides insight into underlined mechanism operating the language improvement

Interventions

DEVICErepetitive transcranial magnetic stimulation (rTMS)

undergo contralesional 1Hz repetitive transcranial magnetic stimulation(rTMS) or high frequency ipsilesional rTMS for 10 daily sessions

DEVICESham stimulation

2-week inhibitory non-dominate hemisphere rTMS program

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

30 Years to 85 Years

Healthy volunteers

Inclusion criteria

* Aphasic stroke in chronic stage (over 3 months)

Exclusion criteria

* No seizure history, no brain surgery history, no electronic device in brain or chest, no dementia

Design outcomes

Primary

Measure	Time frame	Description
Change From Baseline in aphasia level on the Concise Chinese Aphasia Test (CCAT) at 2 Weeks	Up to 12 weeks	linguistic function assessment

Secondary

Measure	Time frame	Description
Change from Baseline in the concomitant nervous status on the Functional magnetic resonance imaging (fMRI) at 2 weeks	Up to 12 weeks	brain activity change in fMRI

Countries

Taiwan

Contacts

Primary ContactPo-Yi Tsai, MD

pytsai@vghtpe.gov.tw886-228757293

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 20, 2026