Parkinson Disease
Conditions
Keywords
working memory, parkinson's disease, cognition, rTMS
Brief summary
Ten sessions of repetitive transcranial magnetic stimulation yield ability to upregulate the function of primary motor cortex and prefrontal cortex that play key roles in motor and frontal memory processing.
Detailed description
Excitatory (\>3Hz) rTMS could facilitate the brain cortex and neuroplasticity that benefits motor control and working memory when the coil is applied over primary motor cortex or dorsolateral prefrontal cortex.
Interventions
DEVICErTMS
High frequency rTMS for 3 to 10 min to increase the excitability of cortex.
BEHAVIORALCognitive training program
A rehabilitation protocol that facilitates attention, memory, execution.
Sponsors
Taipei Veterans General Hospital, Taiwan
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Intervention model description
Real rTMS, sham rTMS
Eligibility
Sex/Gender
ALL
Age
30 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Clinical diagnosis of Parkinson's Disease * With symptoms of cognitive impairments, such as memory, attention, or language decline.
Exclusion criteria
* History of seizure attack * Alzheimer's disease * With cardiac pacemaker implantation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change of Repeatable Battery for the Assessment of Neuropsychological Status | up to 12 weeks | This battery measures the cognitive functions including attention, memory, language, visuospatial domains. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change of Montreal Cognitive Assessment ; MoCA | up to 12 weeks | Assessing cognitive function including delaying recall, attention, executive function, language... |
Countries
Taiwan
Contacts
Primary ContactPo-Yi Tsai, MD
Outcome results
None listed