Antibiotic Therapy, Bronchiectasis, Procalcitonin
Conditions
Brief summary
To explore effectiveness of procalcitonin-guided antibiotic therapy in acute exacerbations of bronchiectasis, and to explore the clinical value of procalcitonin in bronchiectasis.
Interventions
OTHERProcalcitonin
The application of antimicrobial agents is determined by PCT results.
OTHERClinical Experience
The application of antimicrobial agents is determined by clinical experience of doctors.
Sponsors
Qilu Hospital of Shandong University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
1. Bronchiectasis was diagnosed by high-resolution computed tomography based on the criteria published by McShane PJ et al. 2. Acute exacerbations of bronchiectasis. 3. Aged \>= 18 years. 4. Procalcitonin been detected after admission.
Exclusion criteria
1. Associated with chronic obstructive pulmonary disease. 2. Associated with asthma. 3. Traction bronchiectasis caused by pulmonary fibrosis. 4. Rule out other possible cause procalcitonin increased diseases such as cancer, connective tissue disease, active tuberculosis, chronic liver disease and respiratory system than the bacterial infection. 5. Clinical data were incomplete. 6. Can not follow up with the person.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Antimicrobial prescription rate | 14 days |
| Number of days of antimicrobial application | 14 days |
| The number of days in hospital | 14 days |
Secondary
| Measure | Time frame |
|---|---|
| Bacterial resistance rate | 14 days |
| The incidence of complications | 14 days |
| Effective rate of clinical treatment | 14 days |
| mortality rate | 14 days |
| The proportion of patients with at least once acute exacerbation in 6 months | 6 months |
| fungal infection rate | 14 days |
| Quality of life score | 6 months |
| Adverse reaction rate | 14 days |
Outcome results
None listed