Nasopharyngeal Carcinoma
Conditions
Brief summary
Concurrent Chemotherapy for Elderly Patients With Locoregionally Advanced Nasopharyngeal Carcinoma
Detailed description
To evaluate concurrent chemotherapy for elderly patients with locoregionally advanced nasopharyngeal carcinoma treated by intensity-modulated radiotherapy
Interventions
RADIATIONRadiotherapy alone
RADIATIONConcurrent chemoradiotherapy
Sponsors
Zhejiang Cancer Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
Concurrent cisplatin based chemoradiotherapy versus radiotherapy alone
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Previously untreated and histologically confirmed locoregionally advanced nasopharyngeal carcinoma
Exclusion criteria
* A history of another invasive cancer, prior RT to the head and neck area, prior cytotoxic chemotherapy or anti-EGFR therapy or the presence of any serious medical conditions,supposed to live less than 6 months.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| therapeutic success | From date of treatment until the date of completing treatment 1 month later | A combined primary end point, named therapeutic success(TS), was used; it took into account activity, toxicity, and compliance.A TS was defined as a patient completing radiotherapy at the planned dose and schedule (no re-treatment delays beyond 2 weeks), and having an objective response (either complete or partial based on RECIST criteria) without (1) grade 3-4 nonhematological toxicity, (2) complications associated with hematologic toxicity such as febrile neutropenia, infection, bleeding, or transfusion, or (3) any toxicity leading to hospitalization or death. |
Countries
China
Outcome results
None listed