COPD Exacerbation
Conditions
Keywords
COPD, Exercise, High Flow Nasal, Muscle Oxygenation, Pulmonary Rehabilitation
Brief summary
Early pulmonary rehabilitation is recommended after an episode of severe exacerbation of chronic obstructive pulmonary disease (COPD). However, its implementation is challenging particularly as regard exercise training. High flow ventilation in reducing work of breathing and dyspnea may improve exercise tolerance. The aim of this study is to carry out the acute effect of high flow nasal cannula on exercise endurance in post-exacerbation copd patients
Interventions
DEVICEHigh Flow nasal cannula
High intensity Constant Work-Rate exercise test with High Flow Nasal Cannula in COPD patients involved in a Pulmonary Rehabilitation Program after an exacerbation (\< 7 days after hospital discharge). High Flow nasal will be administered through nasal cannula using the Airvo2 (Fisher&Paykel)
Sponsors
Groupe Hospitalier du Havre
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
35 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* a diagnosis of COPD
Exclusion criteria
* exercise contraindication Any musculoskeletal problems, cardiovascular or neurological comorbidities that limits exercise. * pH \< 7,35 * Body temperature \> 38°C * cardiac frequency \> 100 bpm at rest * systolic blood pressure \< 100 mmHg * exacerbation during the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Difference in exercise capacity | The outcome will be measure after every CWRET. The two CWRET will be carried out in different days, separate from 24H minimum for a total time frame of 3 days maximum | Difference in endurance time (TLim) during High Intensity Constant Work-Rate Endurence Test (CWRET) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Difference in Dyspnea and muscular fatigue | The outcome will be measure during every CWRET. The two CWRET will be carried out in different days, separate from 24H minimum for a total time frame of 3 days maximum. Data will be collected every 2 minute during tests and at the end of the exercise | Difference in dyspnea and muscular fatigue using Modified Borg Scale (0 - 10 points) |
| Difference in Oxygen Saturation | The outcome will be measure during every CWRET. The two CWRET will be carried out in different days, separate from 24H minimum for a total time frame of 3 days maximum. Data will be continuously collected during exercise | Difference in Oxygen Saturation using a pulse oximetry (SpO2) |
| Difference in Cardiac Frequency | The outcome will be measure during every CWRET. The two CWRET will be carried out in different days, separate from 24H minimum for a total time frame of 3 days maximum. Data will be continuously collected during exercise | Difference in Cardiac Frequence using a pulse oximetry |
| Difference in peripheral muscle oxygenation | The outcome will be measure during every CWRET. The two CWRET will be carried out in different days, separate from 24H minimum for a total time frame of 3 days maximum. Data will be continuously collected during exercise | Muscle oxygenation will be evaluated using Near-infrared spectroscopy technology. |
| Difference in Respiratory Rate | The outcome will be measure during every CWRET. The two CWRET will be carried out in different days, separate from 24H minimum for a total time frame of 3 days maximum. Data will be continuously collected during exercise | Difference in Respiratory Rate using a Respiratory Inductive Plethysmography |
| Difference in Respiratory Muscle Fatigue | The outcome will be measure during every CWRET. The two CWRET will be carried out in different days, separate from 24H minimum for a total time frame of 3 days maximum. Data will be collected before and 5 minute maximum after exercise | Difference in Respiratory Muscle Fatigue using an electronical manometer |
| Difference in Transcutaneous Carbon Dioxide | The outcome will be measure during every CWRET. The two CWRET will be carried out in different days, separate from 24H minimum for a total time frame of 3 days maximum. Data will be continuously collected during exercise | Difference Transcutaneous Carbon Dioxide using Transcutaneous Carbon Dioxide using a Transcutaneous capnography |
Countries
France
Outcome results
None listed