Cognitive Change
Conditions
Brief summary
The BEST study will investigate the feasibility of cognitive interventions in a randomized, placebo-controlled, clinical trial. The investigators will recruit 45 cognitively normal subjects and engage them in one of three cohorts over an 8 week period, including active reading vs. origami study arms and a placebo group without structured cognitive intervention.
Detailed description
This is a randomized, placebo controlled study investigating the practical implementation and conduct of two cognitive interventions in non-demented subjects. Subjects will be randomized 1:1:1 into three groups including: 1) a Book club that includes weekly one hour meetings and daily reading assignments, 2) Origami lessons (one hour/week) with daily take home Origami activities to complete, and 3) a placebo group with unstructured lifestyle activities (normal lifestyle activities without restraint).
Interventions
BEHAVIORALPlacebo
The placebo group will have unstructured lifestyle activities (normal lifestyle activities without restraint).
BEHAVIORALOrigami
Origami lessons (one hour/week) with daily take home Origami activities to complete
BEHAVIORALReading
Book club that includes weekly one hour meetings and daily reading assignments
Sponsors
University of Kentucky
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Non demented community dwelling elders
Exclusion criteria
* Unable to perform the reading or origami tasks for any reason
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| MOCA | 8 weeks | The Montreal Cognitive Assessment (MOCA) measures general cognitive function |
| FCSRT | 8 weeks | The Free and Cued Selective Reminding Test (FCSRT) measures memory function. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Adherence to protocol | 8 weeks | Objective measures of weekly time devoted to cognitive training activities |
| Electroencephalogram | 8 weeks | resting state electroencephalogram pattern |
| Evoked Related Potential | 8 weeks | Evoked Related Potential P300 using the Bluegrass memory task |
Countries
United States
Outcome results
None listed