Duodenal Ulcer, Gastric Ulcer, Helicobacter Pylori Infection, Stomach Cancer
Conditions
Keywords
Helicobacter pylori, long non-coding RNA, THRIL, PACER, cagA
Brief summary
Helicobacter pylori (H.pylori) is a major human pathogenic bacterium in gastric mucosa which is linked to the development of gastritis, peptic ulcer disease, mucosa-associated lymphoid tissue lymphoma and gastric cancer. However the regulatory mechanism of H.pylori-induced immune response is not clear. Long non-coding RNA (lncRNA) has recently emerged as key post-transcriptional regulators of gene expression, differentiation. The investigators had a preliminary results which THRIL (TNFα and hnRNPL related immunoregulatory lincRNA) and PACER(p50-associated COX-2 extragenic RNA) played a potential role in H.pylori induced inflammatory cascade. However, there wasn't a previous study about expression of THRIL, PACER in a human tissue. Therefore, the investigators aimed to evaluate the expression of THRIL, PACER in patients with gastrointestinal disease according to H.pylori infection.
Interventions
None listed
Sponsors
Yonsei University
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
19 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
1. Over 19 years old 2. Patients with gastric ulcer 3. Patients with duodenal ulcer 4. Patients with stomach cancer 5. Patients with gastrointestinal discomfort symptoms
Exclusion criteria
1. Patients who has done helicobacter pylori eradication 2. Patients who has undergone gastrectomy 3. Patients who has undergone endoscopic submucosal dissection 4. Patients with active upper gastrointestinal bleeding
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Expression of THRIL, PACER | Within 2 weeks after EGD | Expression of THRIL, PACER according to Helicobacter pylori infection by Real-time aRT-PCR |
Countries
South Korea
Contacts
Primary ContactSang Kil Lee, MD
Outcome results
None listed