Metabolic Syndrome, Obesity
Conditions
Brief summary
The hypothesis of this study is that reductions in body weight could improve inspiratory muscle function attenuating the inspiratory metaboreflex in metabolically healthy obese individuals and obese individuals with metabolic syndrome.
Detailed description
Introduction: Peripheral metaboreflex activation appears to be exacerbated in obese individuals with metabolic syndrome. Interestingly, bariatric surgery attenuates the peripheral metaboreflex. Obese individuals have impaired inspiratory muscle function, which can be reversed by the reduction in body weight. Therefore, bariatric surgery could attenuate inspiratory metaboreflex in metabolically healthy obese individuals and obese individuals with metabolic syndrome. Objectives: To investigate the effects of bariatric surgery on inspiratory metaboreflex in metabolically healthy obese individuals and in obese patients with metabolic syndrome. Patients and Methods: A sample comprising of 15 obese subjects with metabolic syndrome, 15 obese subjects without metabolic syndrome and 15 healthy nonobese individuals. These subjects will be submitted to pulmonary function, respiratory muscle strength, inspiratory muscle resistance, exercise tolerance, quality of life, autonomic cardiovascular control and the inspiratory metaboreflex evaluation. The evaluations performed in obese patients with and without metabolic syndrome pre-surgery will be repeated 6 months after bariatric surgery.
Interventions
OTHERBariatric surgery
evaluations pre and post bariatric surgery.
OTHERControl
without intervention, it will be performed only evaluations
Sponsors
University of Cruz Alta
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
Obese with Metabolic Syndrome Inclusion Criteria: * Body mass index (BMI)\> 35 kg / m² * Diagnosis of metabolic syndrome
Exclusion criteria
* Acute health problems in the last month (viral or bacterial infections, accidents, allergic reactions) * Diseases of the nervous system or conditions that affect the understanding or participation in the study * Pregnancy * Type I diabetes mellitus * Arterial hypertension * Dyslipidemias * Coronary artery disease * Left ventricular dysfunction * Any condition interfering with locomotion * Bronchial asthma * Chronic obstructive pulmonary disease * Chronic neuropathies * Use of drugs such as corticosteroids or bronchodilators * Smokers. Obese without Metabolic Syndrome Inclusion Criteria: * Body mass index (BMI)\> 35 kg / m²
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Inspiratory metaboreflex | 6 monhs | It will be induced through a linear inspiratory resistance of 60% of maximal inspiratory pressure |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Respiratory muscle strength | 6 months | It will be determined by manovacuometry. |
| Inspiratory muscle resistance | 6 months | It will be evaluated through a protocol with progressive increase in inspiratory resistance. |
| Pulmonary function | 6 months | It will be assessed by spirometry |
| Exercise tolerance | 6 months | It will be determined by the 6-minute walk test. |
| Quality of life | 6 months | It will be determined through the SF36 questionnaire. |
| Autonomic cardiovascular control | 6 months | It will be determined by spectral analysis |
Countries
Brazil
Contacts
Primary ContactCarine C Callegaro, PhD
Outcome results
None listed