Healthy Volunteers
Conditions
Brief summary
To explore biological mechanisms in human model of induced dyspnea, in order to remove the source of dyspnoea, to modify cerebral impact and to allow the development of targeted therapies.
Detailed description
The aim of the study will be to identify a specific biology and immunology associated with dyspnoea. It will open therapeutic possibilities through a better understanding of the mechanisms of dyspnea. Healthy volunteers will underwent two types of dyspnea. The subjects will be first familiar with both types of dyspnea and dyspnea measurement scales. Different components of dyspnea will be measured. Blood tests will be performed at different times (before dyspnea, during dyspnea, 60 and 90 min after dyspnea)
Interventions
OTHERInduced dyspnea
Biological samples will be assessed during and after breathing discomfort induced by laboratory models of dyspnea (work/effort, air hunger).
Sponsors
Association pour le Développement et l'Organisation de la Recherche en Pneumologie et sur le Sommeil
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* healthy volunteers
Exclusion criteria
* pregnancy * ongoing pain * respiratory disease * high levels of depression, panic disorder, or other significant mental health problems * not fluent in french
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Biomakers in dyspnea | 60 minutes | Biomarkers in human model of induced dyspnea |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Correlation with dyspnea intensity | 60 minutes | Correlation between intensity of dyspnea and biomarkers |
| Correlation with dyspnea type | 60 minutes | Correlation between type of dyspnea and biomarkers |
Countries
France
Outcome results
None listed