Epilepsies, Partial
Conditions
Keywords
epilepsy, cytochrome oxidase redox state, childhood epilepsy, partial epilepsy, NIRS, near-infrared spectroscopy, regional cerebral oxygen saturation
Brief summary
The purpose of this pilot study is to describe the relationship of regional cerebral oximetry and cytoximetry, measured using near-infrared spectroscopy, with seizure activity in the periictal period in children with epilepsy.
Detailed description
Pediatric subjects with partial (focal) epilepsy seizure disorders will be studied using near-infrared spectroscopy for cytochrome c oxidase (CCO) redox state and blood oxygen saturation. Along with routine EEG monitoring, a set of light sensors, called optodes, attached to a net/cap/device that goes over the head will be put on. These optodes will send out very weak red light signals, which will pass through the scalp and bounce back to detectors on the netting. The changes in the light signals will be used to calculate the changes in the various forms of the enzyme CCO, as well as the amount of oxygen in the blood. We hope to use these measurements to study changes in blood flow and cellular energy usage in the brain during seizures, which might help us to understand epilepsy better in the future and design better treatments.
Interventions
DEVICENear-infrared spectroscopy
Measurement of CCO redox state and cerebral oxygenation during epileptic seizures.
Sponsors
Marquette University
Medical College of Wisconsin
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
7 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Pediatric epilepsy patients who can provide assent (lower limit age 7). 2. Diagnosis of partial (focal) epilepsy and/or frequent interictal spike activity on EEG. 3. Clinical EEG supporting diagnosis of partial(focal) epilepsy and/or frequent interictal spike activity
Exclusion criteria
1. History of unrepaired or palliated congenital cyanotic heart disease 2. History of traumatic head injury or head wounds to the extent that precludes safe and consistent placement of NIRS-EEG probes. 3. Guardian does not give consent or patient is unable to consent/assent to participate in the study 4. Clinical care provider or investigator determines the patient is not appropriate candidate for the study 5. Lack of current seizure care plan in Children's Hospital medical record 6. Known sensitivity or allergy to EEG gel
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in CCO redox state and oxygen saturation | 1 week | Regional cerebral saturation of oxygen and/or cytochrome oxidase redox state will change prior, during, and after onset of seizure activity when compared to non-seizure side of brain. |
Countries
United States
Outcome results
None listed