Melanocytic Nevi
Conditions
Brief summary
The objective of this protocol is to further elucidate the genetic mutations that drive melanocytic nevi (benign melanocytic neoplasms, moles). This will be performed by whole genome, whole exome, or targeted sequencing of de-identified specimens. Herein, the investigators plan to isolate DNA from de-identified skin biopsy specimens and blood samples: 1. From melanocytic nevi collected by skin biopsy (a shave or punch biopsy). A part of the tissue will be submitted for routine diagnostic dermatopathology and investigational histomorphologic and immunohistochemical analysis. 2. From corresponding normal tissue (blood). DNA isolated from blood will be used as a normal control when analyzing sequencing data to identify somatic mutations in lesional tissue.
Interventions
OTHERCollecting Nevi
Will be collecting Nevi and completing a DNA analysis, no intervention will be made.
Sponsors
University of California, Davis
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Male or female subjects that are 18 years or older * Subjects with melanocytic nevi\\
Exclusion criteria
* Patients less than 18 years of age * Patients without melanocytic nevi * Patients with a bleeding disorder or are taking anticoagulation medication
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Genome Wide Mutation Analysis | Feb 2017 - December 2018 | Will be performing genome wide mutation analysis to quantify the number of mutations. |
Countries
United States
Contacts
CONTACTMaija Kiuru, MD
CONTACTJohn Robb
Outcome results
None listed