Study Comparing Pulmonary Vein Isolation With the Cryoballoon and Radiofrequency Energy(Contact Force) in the Treatment of Persistent Atrial Fibrillation (AF) (Cryo Vs CF in PerAF)

Study Comparing Pulmonary Vein Isolation With the Cryoballoon and Radiofrequency Energy(Contact Force) in the Treatment of Persistent Atrial Fibrillation (PerAF)

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03053570

Enrollment

200

Registered

2017-02-15

Start date

2017-03-01

Completion date

2018-12-31

Last updated

2017-02-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Persistent Atrial Fibrillation

Keywords

Cryoballoon, Contact Force, Persistent Atrial Fibrillation

Brief summary

The purpose of this study is to perform a prospective, randomised study investigating the safety and efficacy of cryoballoon catheter ablation compared with radiofrequency ablation(contact force), in the treatment of persistent AF.

Detailed description

The hypotheses for this study is that cryothermal energy is as effective and safe as using radiofrequency energy in the treatment of persistent AF and is associated with a better long term outcome.

Interventions

DEVICECryoballoon

use Cryoballoon to isolation the Pulmonary Vein

DEVICERadiofrequency Energy(Contact Force)

use Radiofrequency Energy(Contact Force) to isolation the Pulmonary Vein

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Inclusion criteria

* persistent Atrial Fibrillation; Intolerant to antiarrhythmic medication; Both male or female; Age from 18 to 75 years old.

Exclusion criteria

* Acute myocardial infarction; Coronary artery stent history; Acute severe stroke; Abnormal liver and renal function.

Design outcomes

Primary

Measure	Time frame
Number of participants with successful Pulmonary Vein Isolation	in one year

Countries

China

Contacts

Primary ContactBaopeng Tang, PhD

tangbaopeng1111@163.com+86 13579881111

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026