The Effect of Rhubarb on Sepsis and Post-traumatic Gastrointestinal Function Failure

The Effect of Rhubarb on Sepsis and Post-traumatic Gastrointestinal Function

Status

UNKNOWN

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03048903

Enrollment

400

Registered

2017-02-09

Start date

2016-02-29

Completion date

2018-07-31

Last updated

2017-02-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sepsis

Keywords

Gastrointestinal dysfunction, sepsis, trauma

Brief summary

Random grouping by computer, divided into two groups, a group of rhubarb treatment group, another group for the placebo group.

Detailed description

Patients were randomly divided into two groups, using rhubarb powder or placebo. Rhubarb is commercially certified rhubarb(Rheum palmatum, Sichuan origin, provided by the pharmacy of my hospital), ground into a powder, over 80 mesh steel mesh, Two days before 6g, three times / day, oral or nasal feeding, two days later reduced to 3g, three times / day, oral or nasal feeding; Another group of patients taking placebo, with the same dose of Rhubarb; The overall course of the two drugs was a week.

Interventions

DRUGRheum Palmatum Root

Rhubarb is commercially certified rhubarb(Rheum palmatum , Sichuan origin, provided by the pharmacy of my hospital), ground into a powder, over 80 mesh steel mesh.The dose is 6g in the first 2 days, 3 times / day, oral or nasal feeding,two days later the dose is reduced to 3g, three times / day, oral or nasal feeding.

DRUGStarch Corn

Starch Corn is harmless to people .The use dosage is same as Rheum Palmaturn Root.The dose is 6g in the first 2 days, 3 times / day, oral or nasal feeding,two days later the dose is reduced to 3g, three times / day, oral or nasal feeding.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Intervention model description

Patients were randomly divided into two groups ,using rheum palmatum or placebo

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

1. Age:18-65 year old; 2. Diagnosis: sepsis with gastrointestinal dysfunction (II-III grade AGI); gastrointestinal dysfunction after trauma (II-III AGI); 3. Complete gastrointestinal tract anatomic structure（including the ileum and colon stoma）

Exclusion criteria

1. Hemodynamic instability; 2. Underlying diseases: cardiac function III\ IV, chronic liver dysfunction Child-Pugh score \>9 points; 3. Less than 5 days after surgery for stomach and small intestine，less than 7 days after Colonic surgery, Postoperative gastrointestinal leakage; 4. Abdominal Compartment Syndrome; 5. mechanical ileus 6. active gastrointestinal hemorrhage

Design outcomes

Primary

Measure	Time frame	Description
The remission rate of gastrointestinal dysfunction	2 weeks	The rate of patients who can tolerate 1000Kcal whole protein enteral nutrition in all subjects

Secondary

Measure	Time frame	Description
The ratios of L/M in human urine samples	7 days	The ratios oflactulose / mannitol in human urine samples
citrulline	7 days	The contents of citrulline in human serum samples
D- lactic acid	7 days	The contents of citrulline in human serum samples

Countries

China

Contacts

Primary ContactCHEN De chang, doctor

18918520002@189.cn8618918520002

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026