Intra-articular Injection, Osteoarthritis, Pain Syndrome
Conditions
Brief summary
The aim of present study is to to investigate whether the combined injection of HA and CS was superior than HA alone in the treatment of knee OA.
Detailed description
Intra-articular injection of hyaluronic acid (HA) or corticosteroids (CS) has been widely used with debate on its efficacy in osteoarthritis (OA). The aim of present study is to to investigate whether the combined injection of HA and CS is superior than HA alone in the treatment of knee OA.
Interventions
DRUGhyaluronic acid
intra-Articular injection
DRUGhyaluronic acid and corticosteroids
intra-Articular injection
Sponsors
Zhongda Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
50 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
According to radiographic findings, patients who are suffering from knee OA for over 3 months have to be stage II-IV according to the Kellgren-Lawrence (KL) grade by a senior radiologist. The diagnosis of symptomatic knee OA is based on American Rheumatism Association classification criteria for knee osteoarthritis.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| VAS | 6 months | Visual analog scale |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| WOMAC | 6 months | Western Ontario and McMaster University Osteoarthritis Index |
| Knee flexion motion | 6 months | Knee flexion motion |
Countries
China
Contacts
Primary ContactShan-zheng Wang, MD
Outcome results
None listed