Acute Kidney Injury, Lung Transplantation
Conditions
Brief summary
Evaluation of acute kidney injury, renal recovery and development of chronic kidney disease in patients undergoing lung transplantation
Detailed description
It is well described that acute kidney injury and development of chronic kidney disease significantly impact short- and long-term survival after lung transplantation. However, there is limited data about prevalence of kidney disease according to current KDIGO consensus guidelines. It is the aim of this study to describe short- and long-term renal outcomes following lung transplantation. Selected patients who underwent prospective pretransplant renal functional reserve testing with high oral protein load will be analyzed separately in respect to occurrence of acute kidney injury following lung transplantation and development of chronic kidney disease.
Interventions
OTHERNo intervention
No intervention
Sponsors
University of Giessen
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
For retrospective analysis for all patients undergoing lung transplantation: Inclusion Criteria: * Older than 18 years
Exclusion criteria
* Patients with eGFR \<15ml/min/1.73m2 or with chronic dialysis treatment prior LTx * Patients undergoing retransplantation and multiorgan transplantation For prospective study involving patients with pretransplant renal functional reserve testing
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Impact of acute kidney injury (AKI) after lung transplantation on long-term renal function decline. | 7 days | AKI defined by KDIGO consensus criteria |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Impact of sustained reversal versus non-recovery after AKI on long-term renal function decline after lung transplantation. | 3 years | AKI and CKD defined by KDIGO consensus criteria |
| Risk factors associated with development of AKI and CKD after lung transplantation | 3 years | AKI and CKD defined by KDIGO consensus criteria |
| Whether development of CKD is an independent risk factor for increased rejection rate and death after lung transplantation. | 3 years | CKD defined by KDIGO consensus criteria |
| Association between pretransplant renal functional reserve with acute kidney injury after after lung transplantation. | 7 days | AKI defined by KDIGO consensus criteria |
| Association between pretransplant renal functional reserve and renal function loss after lung transplantation. | 1 year | 24h-creatinine clearance, estimated glomerular filtration rate |
Countries
Germany
Outcome results
None listed