The Effect of Roux-en-Y Gastric Bypass on Bone Turnover

Bone Mineral Density and Markers of Bone Turnover After Roux-en-Y Gastric Bypass

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03046147

Enrollment

Registered

2017-02-08

Start date

2015-09-30

Completion date

2017-09-30

Last updated

2017-02-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bone Loss, Gastric Bypass Surgery, Obesity

Brief summary

Bone mineral density (BMD) is decreased after Roux-en-Y gastric bypass (RYGB) but whether RYGB induces changes in BMD beyond adaptation to major weight loss is not known. We aim to investigate BMD changes in weight bearing (hip, lumbal columna) and in non-weight bearing (forearm) regions before and after maximal weight loss at 1 year and after weight stabilisation at 4 years after RYGB. Moreover, plasma markers of bone turnover will be studied at fasting and during oral glucose tolerance test.

Interventions

PROCEDURERoux-en-Y gastric bypass

Roux-en-Y gastric bypass surgery for morbid obesity

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Healthy volunteers

Inclusion criteria

* Participation in previos study ((NCT 01202526)

Exclusion criteria

* Treatment of osteoporosis

Design outcomes

Primary

Measure	Time frame	Description
Changes in bone mineral density of non-weight bearing bone	1 year, 4 years	DXA scans of forearm
Changes in bone mineral density of weightbearing bone	1 year, 4 years	DXA scans of hip and lumbal columna

Secondary

Measure	Time frame	Description
Plasma markers of bone turnover	1 week, 3 months, 1 year, 4 years	At fasting

Countries

Denmark

Contacts

Primary ContactKirstine N Bojsen-Møller, MD, PhD

kirstine.bojsen-moeller@regionh.dk4538626371

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026