Spinal Cord Injuries
Conditions
Brief summary
The investigators have recently shown in two pilot incomplete SCI patients that long-term paired associative stimulation is capable of restoring voluntary control over some paralyzed muscles and enhancing motor output in the weak muscles (1). In this study, the investigators will administer long-term paired associative stimulation to incomplete SCI patients in a long-term manner, keeping each patient in the study for as long as continuous improvement is observed.
Interventions
Paired associative stimulation (PAS) administered 3 times per week. PAS comprises transcranial magnetic stimulation (eXimia magnetic stimulator, Nexstim Ltd, Helsinki, Finland) and peripheral nerve stimulation (given with Dantec Keypoint® electroneuromyography device (Natus Medical Incorporated, Pleasanton, CA, USA)).
Sponsors
Validia Rehabilitation
University of Helsinki
Helsinki University Central Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* incomplete SCI
Exclusion criteria
* epilepsy * metal inclusion in the head area * pacemaker * hearing device * high intracranial pressure
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Daniels and Worthingham's Muscle Testing | 2 days after the last stimulation session |
Countries
Finland
Outcome results
None listed