Cycling Performance, Muscular Adaptations, Substrate Utilization
Conditions
Brief summary
The investigators will examine the long-term effects of a combined training and diet intervention that, acutely, increases fat oxidation during exercise. This is done with a 4 week intervention study with moderately trained cyclists. Performance is tested pre and post intervention and muscle biopsies are obtained.
Interventions
OTHERCombined exercise and diet intervention
Both groups exercise 6 times per week in 4 weeks conducted as 3 evening and 3 morning sessions per week. Both groups receive dietary products to be consumed immediately before and after each evening and morning session, respectively. One group conduct morning sessions in a fasted state, the other conduct the morning sessions in a fed state. Performance pre and post is measured, and muscle biopsies are obtained.
Sponsors
Team Denmark
University of Aarhus
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
MALE
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* 18-45 years * VO2-max\>55 ml/kg/min * No smokers * Training 6 hours per week (cycling) * Training experience for more than 3 years.
Exclusion criteria
* Less than 2 g carbohydrate/kg/day
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Time trial performance measured in Watts | Change from Baseline and after 4 weeks of training | 30 min time trial after 90 minutes of intensive cycling. The average amount of Watts during the 30 minutes will be measured. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Protein expression in skeletal muscle tissue | Baseline and after 4 weeks of training | Amount of mitochondrial proteins and enzymes will be measured with a Western Blotting technique |
| The absolute amount of carbohydrate and fat which is metabolised during morning exercise, measured in grams/minute | Baseline and after 4 weeks of training | Fat and carbohydrate oxidation during exercise measured and estimated with indirect calorimetry. |
Outcome results
None listed