Sildenafil Citrate of in Vitro Fertilization After Multiple IVF Failures Attributed to Poor Endometrial Development

Effect of Sildenafil Citrate on the Outcome of in Vitro Fertilization After Multiple IVF Failures Attributed to Poor Endometrial Development

Status

UNKNOWN

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03044561

Enrollment

Registered

2017-02-07

Start date

2017-01-31

Completion date

2017-08-10

Last updated

2017-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

IVF Failure

Brief summary

The aim of this study is to evaluate the effect of sildenafil citrate on endometrial development in women with history of recurrent implantation failure after IVF

Detailed description

sildenafil citrate may increase endometrial thickness in women with recurrent IVF failure attributed to poor endometrial development

Interventions

DRUGSildenafil Citrate

25 mg orally, 4 times per day for 21 days

DRUGmatching placebo

orally, 4 times per day for 21 days

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Age

20 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

* (1) cases of infertility, older than 20 years of age and not older than 40 years. * (2) Body mass index (BMI):20-29. * (3) women have experienced two or more implantation failure attributed to inadequate endometrial development.

Exclusion criteria

* (1) Uterine abnormalities (e.g. septate, bicornuate and fibroid uterus, Asherman Syndrome). * (2) Any contraindication to sildenafil citrate or any of the components of its formulation including: * Concurrent use of organic nitrites and nitrates. * Severe hepatic impairment. * Severe renal impairment. * Hypotension. * Recent stroke or heart attack.

Design outcomes

Primary

Measure	Time frame	Description
endometrial thickness measures	21 days	we will measure endometrial thickness by US in women with recurrent implantation failure

Countries

Egypt

Contacts

Primary Contactahmed khairy, professor

01090808047

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026