Muscle Relaxation
Conditions
Brief summary
This is an adaptative study where each participant's rocuronium dose will depend on the previous patient's response, being higher if it was not enough and lower if it was more than enough.
Detailed description
Rocuronium is one of the most used neuromuscular blockers to help intubation and to relax abdominal wall for laparoscopic surgery. Rocuronium intubation dose can be enough for intubation but not last enough for excellent laparoscopic conditions. There is little variation in time from anesthesia induction to the end of the laparoscopy for cholecystectomy and avoiding excess rocuronium dose can help providing excellent conditions and fast track extubation. Dixon's up-and-down method will guide this dose-finding study for the ED50.
Interventions
DRUGrocuronium
intravenous rocuronium infusion
Sponsors
Brasilia University Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Masking description
Participant receives hypnotic (propofol) before we use the drug
Intervention model description
Dose-finding using Dixon's up-and-down adaptative clinical trial
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* general anesthesia
Exclusion criteria
* deny participation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Excellent laparoscopic conditions | 30 minutes | Subjective laparoscopic conditions for surgery, assessed by the main surgeon, as excellent or not |
Countries
Brazil
Outcome results
None listed