Serum TRAP-5b Levels in Patients With Generalized Chronic Periodontitis

The Effect of Non-surgical Periodontal Therapy With or Without Systemic Administration of Amoxicillin and Metronidazole on Serum Levels of TRAP-5b in Patients With Generalized Chronic Periodontitis - A Comparative Clinical Study

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03043066

Enrollment

Registered

2017-02-03

Start date

2016-03-01

Completion date

2016-10-01

Last updated

2017-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Periodontitis

Keywords

Chronic Periodontitis, TRAP-5b, Non-surgical periodontal therapy, Systemic antibiotics

Brief summary

To compare the effect of non-surgical periodontal therapy with or without systemic administration of amoxicillin and metronidazole on the concentration of serum levels of TRAP-5b in patients with generalized chronic periodontitis.

Detailed description

30 Chronic periodontitis subjects were divided into two groups- group A underwent scaling and root planing and group B underwent scaling and root planing with systemic administration of amoxicillin of 500 mg and metronidazole of 400 mg thrice daily for 7 days. Periodontal parameters probing pocket depth and clinical attachment level were measured at baseline and at 3rd month. Serum TRAP-5b levels were also measured at baseline, 1 month and at 3rd month.

Interventions

PROCEDUREScaling and root planing

subjects underwent full mouth supragingival and subgingival scaling

DRUGscaling and root planing along with antibiotic intervention

subjects underwent full mouth supragingival and subgingival scaling along with antibiotic intervention of amoxicillin of 500 mg and metronidazole of 400 mg thrice daily for 7 days

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Investigator)

Intervention model description

Group A - scaling and root planing Group B - scaling and root planing along with antibiotic intervention of amoxicillin and metronidazole

Eligibility

Sex/Gender

ALL

Age

30 Years to 45 Years

Healthy volunteers

Yes

Inclusion criteria

* Presence of atleast 20 teeth * more than 30% of sites with clinical attachment loss of ≥ 5 mm * non-smokers * no previous history of periodontal therapy

Exclusion criteria

* systemic diseases * under antibiotics or anti-inflammatory drugs within previous 3 months * pregnant and lactating women * allergic to antibiotics

Design outcomes

Primary

Measure	Time frame	Description
Serum levels of TRAP-5b	Baseline and 3 months	Concentration of serum levels of TRAP-5b was assessed at baseline and at 3rd month using ELISA method.

Secondary

Measure	Time frame	Description
Probing pocket depth	Baseline and 3 months	Probing pocket depth was measured using Williams periodontal probe at baseline and at 3rd month
Clinical attachment level	Baseline and 3 months	Clinical attachment level was measured as a distance between base of pocket and a fixed point on the crown, such as cemento-enamel junction at baseline and at 3rd month.

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026