Serum Lipid Levels and Lp-PLA2 in Chronic Periodontitis

The Association Between Periodontal Status, Serum Lipid Levels and Lipoprotein Associated Lipophosphase A2(Lp-PLA2) in Chronic Periodontitis Subjects and Healthy Controls: A Case Control Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03041480

Enrollment

Registered

2017-02-02

Start date

2015-02-02

Completion date

2015-11-26

Last updated

2017-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Periodontitis (Disorder)

Keywords

chronic periodontitis, lipids, Lp-PLA2

Brief summary

To assess the association between periodontal parameters, serum lipid profile and Lp-PLA2 level in systemically healthy Chronic Periodontitis subjects and healthy controls.

Detailed description

Seventy five participants were divided into 3 groups. The groups consisted of GROUP I- generalized severe chronic periodontitis, GROUP II- generalized moderate chronic periodontitis and GROUP III- systemically and periodontally healthy volunteers who served as control. The selected patients were then evaluated for periodontal parameters, lipid profile and Lp-PLA2.

Interventions

DIAGNOSTIC_TESTserum lipid levels and Lp-PLA2

Estimation of Total Cholesterol, triglyceride, High density lipoprotein, Low density lipoprotein, very low density lipoprotein and Lipoprotein associated lipophosphase A2 in chronic periodontitis

Study design

Observational model

CASE_CONTROL

Time perspective

OTHER

Eligibility

Sex/Gender

ALL

Age

35 Years to 64 Years

Healthy volunteers

Yes

Inclusion criteria

Group I: 1. Subjects with age ≥ 35 years. 2. Presence of at least 24 teeth, with Clinical attachment loss (CAL) ≥ 5mm in more than 30% of sites. Group II: 1. Subjects with age ≥ 35 years. 2. Presence of at least 24 teeth, with Clinical attachment loss (CAL) between 3-4 mm in more than 30% of sites. Group III: 1. Subjects with age ≥ 35 years. 2. Healthy and intact periodontium

Exclusion criteria

1. Presence of any systemic disease or conditions that could affect periodontal tissues. 2. History of periodontal treatment in past 6 months. 3. Smoking and alcoholism 4. Anomalies of blood and immune system 5. Systemic medication or antibiotic treatment for the previous 6 months. 6. Pregnant females.

Design outcomes

Primary

Measure	Time frame	Description
Estimation of serum Lp-PLA2	9 months	Serum Lp-PLA2 was estimated in all the groups using ELISA

Secondary

Measure	Time frame	Description
Estimation of serum lipid profile	9 months	Serum Total cholesterol, triglyceride, High density lipoprotein, Low density lipoprotein and very low density lipoprotein

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026