Respiratory Muscle Training in Hemodialysis Patients

Respiratory Muscle Training in Hemodialysis Patients: Effects on Physiologic Parameters and Endothelium-related Biomarkers

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03041155

Enrollment

Registered

2017-02-02

Start date

2017-02-01

Completion date

2017-04-20

Last updated

2017-07-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Renal Failure

Brief summary

The research protocol is a Randomized Clinical Trial that has the effectiveness of a given respiratory muscle training protocol over the indicative variables: Pulmonary function; Markers of oxidative stress and inflammation, endothelial markers and Quality of life in patients with chronic kidney disease undergoing hemodialysis. According to the Investigators, this topic was proposed since it is known that several pulmonary complications occur as a consequence of chronic kidney disease due to uremic myopathy. Therefore, the hypothesis is that the application of a respiratory muscle training protocol will contribute positively pulmonary functionality and a decrease in oxidative stress and inflammation in chronic kidney patients, consequently, will bring improvement in the quality of life for these patients. The Patients will be divided into two groups: control group - No intervention of the Muscular Training (CG) And Intervention Group (GI). The intervention protocol will be composed of respiratory muscle training And lasts for two (2) months, with three (3) visits per week. It will be carried out through Threshold PeP appliance. The twelve (12) first training sessions will have a total duration of 30 minutes 15 minutes with inspiratory load of 20 cmH2O and 15 minutes with expiratory load of 20 CmH 2 O; and the others (12) twelve sessions will last 40 minutes each, with 20 minutes with an inspiratory load of 20 CmH2O and 20 minutes with expiratory load of 20 cmH2O. The variables evaluated will be: muscular strength Respiratory (maximum inspiratory pressure and maximum expiratory pressure - Pimáx and Pemáx); Lung function (Slow Vital Capacity - CVL, forced expiratory volume in the first minute - VEF1, Vital Capacity Forced - CVF and Maximum Voluntary Ventilation - VVM); Serum levels of oxidative stress markers, endothelial markers and endothelin.

Interventions

BEHAVIORALMuscle respiratory training

Muscle respiratory training during hemodialysis sessions

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

* Maintenance hemodialysis for more than 3 months * No COPD diagnosis

Exclusion criteria

* Decompensated Heart failure * Acute coronary disease in the last 3 months * Active infection

Design outcomes

Primary

Measure	Time frame	Description
endothelium glycocalyx biomarkers	8 weeks	plasma syndecan-1 (ng/mL)

Secondary

Measure	Time frame	Description
Endothelium biomarker	8 weeks	ICAM (ng/mL)
Endotehlium Biomarker	8 weeks	VCAM(ng/mL)
Aberrant angiogenesis	8 weeks	Angiopoietin-2 (ng/mL)
Oxidative stress	8 weeks	Plasma Malondialdehyde (mmol/L)
Mean blood pressure	8 weeks	Blood pressure (mmHg)

Countries

Brazil

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026