Immunological Memory Induced by the 13valent Pneumococcal Conjugate(PCV13) and 23valent Plain Polysaccharide Vaccine(PPV23) in HIV-infected Patients

Study of the Immunogenicity and Immunological Memory Induced by the 13valent Pneumococcal Conjugate(PCV13) and 23valent Plain Polysaccharide Vaccine(PPV23) in HIV-infected Adults

Status

UNKNOWN

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03041051

Enrollment

Registered

2017-02-02

Start date

2015-12-31

Completion date

2017-03-31

Last updated

2017-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

HIV Infection

Brief summary

The purpose of this study is to determine the effect of a combined vaccination schedule of the 13-valent pneumococcal conjugate (PCV13) and 23valent plain polysaccharide vaccine (PPV23) on the establishment of immunological memory in HIV-infected adults on ART.

Interventions

BIOLOGICALPCV13

BIOLOGICALPPV23

Study design

Allocation

NON_RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

PREVENTION

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* CD4 T cell count \>200cells/μl * on ART

Exclusion criteria

* no previously recorded allergy to PCV, PPV23 * no intravenous immunoglobulin (IVIG) given within the previous 6 months * no other vaccine given within the previous 6 months

Design outcomes

Primary

Measure	Time frame	Description
immunoglobulin G (IgG) B memory cell response one month post vaccination (measured by flow cytometry)	One month post-PCV13, PPV23	immunoglobulin G (IgG) B memory cell response one month post vaccination (measured by flow cytometry)
immunoglobulin M (IgM) B memory cell response one month post vaccination (measured by flow cytometry)	One month post-PCV13, PPV23	immunoglobulin M (IgM) B memory cell response one month post vaccination (measured by flow cytometry)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 24, 2026