Risk Factors for Staphylococcus Aureus Surgical Site Infections in Orthopedic and Trauma Surgery

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03040960

Acronym

ISO

Enrollment

150

Registered

2017-02-02

Start date

2016-08-31

Completion date

2018-08-31

Last updated

2017-10-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Orthopedic Disorder, Staphylococcus Aureus, Surgical Wound Infection, Traumatology

Keywords

infection, wound infection, surgical wound infection, Staphylococcal infections, wound and injuries, postoperative complications, Gram-positive bacterial infections, bacterial infections

Brief summary

The most commonly identified organism for Surgical Site Infection (SSI) in orthopedic surgery is Staphylococcus aureus but risk factors for mono microbial S.aureus SSI are not well-known. The aim of this study was to evaluated the incidence rate of S. aureus SSI over the years and risk factors of these infections in a french University Hospital.

Detailed description

Surgical site infections (SSI) in orthopedic surgery are responsible for reduced quality of life, increased length of hospital stay and costs. The most commonly identified organism is Staphylococcus aureus but risk factors for mono microbial S.aureus SSI are not well-known.The aim of this study was to evaluate the incidence rate trend of S. aureus SSI over the years and risk factors of theses infections in a french University Hospital. The knowledge obtained by this study will enable identification of the surgical patients most at risk of developping S. aureus SSI, and who would probably benefit most from new interventions given prophylactically and specifically to prevent S. aureus infections.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

16 Years to No maximum

Healthy volunteers

Inclusion criteria

* orthopedic or traumatology surgeries performed in Grenoble University Hospital, * from january 1st 2012 to april 30th 2015, * the subject is undergoing one of the following surgical procedures : knee and hip arthroplasties, osteosynthesis of proximal femur and other osteosynthesis except skull and spine. * the subject is 16 years of age or older

Exclusion criteria

* non orthopedic or trauma surgery performed in Grenoble University Hospital, * spine surgeries, * surgeries of the hand, scaphoid and carpal bones.

Design outcomes

Primary

Measure	Time frame	Description
Risk factors of S. aureus surgical site infections.	up to 1 year following surgery	univariate analysis of potential risk factors. Data with p value less than 0.1 were included in a logistic regression model

Secondary

Measure	Time frame	Description
The incidence rate trend of S. aureus SSI over the year.	from january 1st 2012 to april 30th 2015	linear regression slope test of S. aureus SSI incidence rates by years

Countries

France

Contacts

Primary ContactCaroline Landelle, PH

clandelle@chu-grenoble.fr0033476765643

Outcome results