Changes in Renal Function and Body Composition in Pulmonary Hypertension

Prospective Evaluation of Changes in Renal Function and Body Composition in Patients With Pulmonary Hypertension

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03039972

Enrollment

500

Registered

2017-02-01

Start date

2017-01-25

Completion date

2020-07-09

Last updated

2020-12-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pulmonary Hypertension, Renal Function Abnormal

Brief summary

Changes in renal function and body composition in patients with pulmonary hypertension

Detailed description

This prospective single-center study is designed to analyze changes in renal function and body composition in patients with suspected or pre-diagnosed pulmonary hypertension at pulmonary hypertension outpatient clinic, University Hospital Giessen and Marburg, Campus Giessen.

Interventions

DIAGNOSTIC_TESTNo intervention

No intervention

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* Subjects older than 18 years at pulmonary hypertension outpatient clinic * Subjects who signed informed consent forms

Exclusion criteria

* Patients refusing to participate or withdraw consent during follow-up

Design outcomes

Primary

Measure	Time frame	Description
Changes in renal function in patients with pulmonary hypertension	1 year	Estimated GFR based on Chronic Kidney Disease Epidemiology Collaboration-creatinine-cystatin C will be used to determine renal function at baseline and at 1 year follow-up

Secondary

Measure	Time frame	Description
Changes in hydration status in patients with pulmonary hypertension	1 year	Bioimpedance analysis will be used to determine hydration status at baseline and at 1 year follow-up
Changes in nutritional status in patients with pulmonary hypertension	1 year	Bioimpedance analysis will be used to determine lean tissue and fat mass at baseline and at 1 year follow-up
Prognostic value of baseline renal function, hydration and nutritional status on pulmonary hypertension-associated morbidity and mortality	1 year	pulmonary hypertension-associated morbidity and mortality (defined as escalation of pulmonary hypertension-specific therapy, unscheduled hospitalization and all-cause mortality) will be prospectively assessed during follow-up period

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026