Safety of Different Forms of Creatine

Short-Term Safety and Dose Effects of Different Forms of Creatine

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03039829

Acronym

NB9

Enrollment

Registered

2017-02-01

Start date

2016-01-31

Completion date

2016-05-31

Last updated

2017-02-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nutritional Supplements

Brief summary

This study will aim to determine whether ingesting creatine nitrate (CrN) at higher doses will differentially affect hemodynamic variables compared to a placebo.

Detailed description

This study will examine the short-term (7 day) characteristics of ingesting creatine nitrate (CrN) compared to placebo on Chem-15 blood safety, heart rate, blood pressure, heart rate and blood pressure reactivity and self-reported side effects.

Interventions

DIETARY_SUPPLEMENTCreatine nitrate, low dose

Creatine nitrate at 3.0 grams (2.0 grams creatine, 1.0 gram nitrate, 3.0 grams dextrose)

DIETARY_SUPPLEMENTCreatine nitrate, high dose

Creatine nitrate at 6.0 grams (4.0 grams creatine, 2.0 grams nitrate)

DIETARY_SUPPLEMENTPlacebo

Placebo at 6.0 grams (6.0 grams dextrose)

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

HEALTH_SERVICES_RESEARCH

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

* Apparently healthy * At least 6 months immediate prior history of resistance training including bench press and leg press or squat

Exclusion criteria

* A history of treatment for metabolic disease (i.e., diabetes), hypertension, hypotension, thyroid disease, arrhythmias and/or cardiovascular disease * Use of prescription medication (birth control is allowed) * Pregnant or nursing or plan to become pregnant during the next month * Creatine or nitrate use in the last eight weeks * History of smoking * History of drinking (i.e., 12 drinks per week or more) * Use of nonsteroidal anti-inflammatory drugs (NSAIDs) including ibuprofen (Advil, Motrin, Nuprin, etc.), indomethacin (Indocin), naproxen (Aleve, Anaprox, Naprelan, Naprosyn), piroxicam (Feldene)

Design outcomes

Primary

Measure	Time frame
Measuring the blood pressure response to creatine nitrate ingestion	7 days
Measuring the heart rate response to creatine nitrate ingestion	7 days

Secondary

Measure	Time frame
Measuring a blood chemistry panel 15 response to creatine nitrate ingestion	7 days
Measuring the one Repetition Maximum (1 RM) muscle strength response to creatine nitrate ingestion	7 days
Measuring the repetitions to failure muscle endurance response to creatine nitrate ingestion	7 days
Measuring self-reported side effects of creatine nitrate ingestion	7 days

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026