Endoscopic Submucosal Dissection for Early GI Neoplasia in the United Kingdom

Endoscopic Submucosal Dissection in the Treatment of Early Gastrointestinal Neoplasia: A UK Cohort Study to Assess Effectiveness and Safety

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03039309

Acronym

ESDUK

Enrollment

500

Registered

2017-02-01

Start date

2016-08-05

Completion date

2028-08-05

Last updated

2026-09-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Endoscopic Submucosal Dissection

Keywords

Endoscopic Submucosal Dissection

Brief summary

Multicentre cohort study on the use of endoscopic submucosal dissection for the treatment of early gastrointestinal neoplasia.

Detailed description

Data will be collected from participating centres on en bloc resection, curative resection, R0 resection and complications/adverse events over a 2 year follow up period. Demographic details on the patients included in the study will be captured alongside details on the size and location of their early gastrointestinal dysplastic/neoplastic lesions.

Interventions

PROCEDUREEndoscopic Submucosal Dissection

Endoscopic submucosal dissection is an endoscopic resection technique that utilises an endoscopic knife to remove lesions within the gastrointestinal tract in an en bloc fashion.

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Male or Female, aged 18 years or above undergoing endoscopic submucosal dissection * Participant is able to give informed consent for participation in the study

Exclusion criteria

* Patients under the age of 18 * Patients unable to give informed consent

Design outcomes

Primary

Measure	Time frame	Description
Curative resection rate	2 years	% of successful resections free of disease at follow up endoscopy by the end of the follow up period (2 years)

Secondary

Measure	Time frame	Description
En bloc resection rate	At the time of procedure	% of en bloc resections obtained at the time of initial endoscopic submucosal dissection
Complication rates	28 days post procedure	% of complications noted within 28 days following endoscopic submucosal dissection
Mortality rates	2 years	% of patients alive at the end of the 2 year follow up

Countries

United Kingdom

Contacts

CONTACTProf Pradeep Bhandari, MBBS, MD

pradeep.bhandari@porthosp.nhs.uk02392286000

CONTACTSharmila Subramaniam, MBBS

Sharmila.Subramaniam@porthosp.nhs.uk02392286000

PRINCIPAL_INVESTIGATORProf Pradeep Bhandari, MBBS, MD

Portsmouth Hospitals NHS Trust

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Sep 18, 2026