Hepatitis C, Hepatitis C, Chronic
Conditions
Brief summary
The investigators aim to determine the prevalence of hepatitis C in the adult children of female baby boomers. During the years baby boomers were becoming pregnant, hepatitis C testing was either not available or was not standard of care. Because of this, participants' children may be unaware of participants' risk of hepatitis C.
Interventions
OTHEREligibility Screening
Investigators will call eligible mothers to screen for the possibility that eligible mothers may have passed HCV on to adult children. Investigators will consent these mothers to contact the adult child(ren), as the child(ren) must be informed of the mother's HCV status, if not already known.
DIAGNOSTIC_TESTHCV test
Adult children will be invited to Penn or a Penn affiliate to have labwork, testing HCV antibody and HCV quant. If the quant comes back positive, investigators will also test genotype and fibrosure.
Sponsors
Gilead Sciences
University of Pennsylvania
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 72 Years
Healthy volunteers
Yes
Inclusion criteria
Mothers: * Born between 1/1/45-12/31/64 * Black or white race * Active or prior infection with hepatitis C * Have at least one living adult child over the age of 18 Children: * ≥18 years of age * Born to mother with current or prior HCV infection, with likely timing of HCV acquisition prior to or during pregnancy * Mother gave informed consent for child to be approached for study participation
Exclusion criteria
Mothers: \- Unwilling to disclose hepatitis C status to children
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| HCV prevalence | Within 1 week of labwork at first study visit | Prevalence of HCV in adult children of female baby boomers who have or have had HCV |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Liver fibrosis | Within 2 weeks of diagnosis of HCV | Level of liver fibrosis (detected through fibrosure test) found in adult children diagnosed as HCV-positive |
| HCV genotype | Within 6 weeks of diagnosis of HCV | HCV genotype for adult children diagnosed as HCV-positive |
Countries
United States
Outcome results
None listed