Pressure Ulcers Stage III, Pressure Ulcer, Stage IV
Conditions
Brief summary
To investigate whether an oral nutritional supplement of a mixture of arginine, glutamine and HMB for a maximum period of four weeks is more beneficial than the standard dietary approach to the healing of pressure ulcers, and to examine whether the use of it can reduce admissions and length of hospitalizations for these patients.
Detailed description
All patients would be assessed by a dietitian to ensure them receiving nutritional support of at least 30 kcal/kg/day and of at least 1.2 g/kg/day of protein regardless of feeding method. During the study period, vitamin C and zinc supplement would not be given. Nutritional supplement other than that provided by the dietitian to meet the energy and protein requirement would not be given. The pressure ulcers would be cared according to the Basic nursing standards for patient care: Wound dressing - Version 5 published by the Hospital Authority Head Office. The treatment group would also be given 2 Sackets of a mixture of arginine, glutamine and HMB (ABOUND) every day for a maximum period of 4 weeks, either orally or via enteral feeding.
Interventions
DIETARY_SUPPLEMENTABOUND
an oral mixture of arginine, glutamine and beta-hydroxy-beta-methylbutyrate
Sponsors
Wong Tai Sin Hospital
Our Lady of Maryknoll Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Inpatients of medical and geriatric wards of OLMH and WTSH 2. Aged 18 and older with stage III - IV lesions 3. Patients fed orally or through feeding tubes were included
Exclusion criteria
1. Patients with history of using the nutritional supplement (ABOUND) in previous three months 2. Patients with cellulitis, wounds with purulent discharge or osteomyelitis or sepsis 3. Patients requiring protein restriction 4. Patients with poorly controlled diabetes mellitus (latest HbA1C \> 8.5) (healing process may be affected 5. Patients under palliative care
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| percentage change in pressure ulcer area | 4 weeks |
| change in Pressure Ulcer Scale for Healing (PUSH) | 4 weeks |
Secondary
| Measure | Time frame |
|---|---|
| number of hospital admissions | six months |
| length of hospitalisation | six months |
Countries
Hong Kong
Contacts
Primary ContactKwok Man Lo, FHKAM (Med)
Backup ContactKa Ying Doris Miu, FHKAM (Med)
Outcome results
None listed