Idiopathic Parkinson Disease
Conditions
Brief summary
The purpose of this study is to assess whether tear secretion in patients with Parkinson's disease will be altered to exhibit a characteristic or diagnostic biomarker profile, that will be reflected in changes in the protein composition of tear fluid, which can be measured relatively easily, cost-effectively, and non-invasively. Tear fluid samples will be collected from Parkinson's patients, and through biochemical assays, the profile of proteins in tears will be characterized and compared to that from control subjects. The profiles will be analyzed with respect to any differences between Parkinson's patients and control subjects. If differences appear, the levels of these potential biomarkers in Parkinson's patients will be compared to the severity of their disease.
Interventions
None listed
Sponsors
University of Southern California
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
35 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* established Parkinson's Disease for at least 6 months * Healthy controls without neurological illness
Exclusion criteria
* currently taking anti-cholinergic medication * dementia * have an exposure to neuroleptic medications other than Quetiapine or Clozapine in the 6 months prior to screening * have an active eye infection or have had eye surgery within 3 months prior to screening * control subjects will be excluded if they have a history of neurological disease * PD subjects will be excluded if they have an atypical Parkinsonian syndrome
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Tear protein composition to discriminate between participants with Parkinson's disease and healthy controls | up to 12 months | 4 potential biomarkers will be evaluated in collected tear fluid and will be followed longitudinally for 3-4 visits |
Countries
United States
Outcome results
None listed