Healthy
Conditions
Keywords
Exercise
Brief summary
The purpose of this study is to find out whether exercise training leads to changes in the blood that are produced by exercised muscles and if these changes produce new hormones that affect the body's regulation of sugar and body weight.
Interventions
OTHERExercise Intervention
10 Week aerobic exercise training
Sponsors
Daiichi Sankyo
Joslin Diabetes Center
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Intervention model description
Single Group Assignment
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
\- Age between 18-35. Body mass index (BMI) must be ≥18.5 and ≤27 kg/m2. HbA1c values ≤5.7%
Exclusion criteria
* Age \<18 and \>50 * HbA1c ≥ 5.7%; heart or lung disease * acute systemic infection accompanied by fever, body aches, or swollen lymph glands * BMI \> 27 kg/m2 * current dieting or weight loss efforts * current pregnancy or breastfeeding * known history of HIV/AIDS; cancer * biochemical evidence of renal or hepatic dysfunction; renal or liver disease demyelinating diseases such as multiple sclerosis or amyotrophic lateral sclerosis * recent blood donation * clinical history of stroke * hypertension (systolic \> 140 mmHg or diastolic \> 90 mmHg) * type 1 or 2 diabetes; inability to exercise at 50% of predicted heart rate (HR) reserve at baseline * Participants taking beta-blockers Participants who screen positive for The American Heart Association's contraindications to exercise testing
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in circulating proteins in the blood. | Baseline vs. Post 10 Week Training. |
Countries
United States
Outcome results
None listed